Efficacy of bortezomib therapy for extramedullary relapse of myeloma after autologous and non-myeloablative allogeneic transplantation.
نویسندگان
چکیده
We report the successful use of bortezomib to treat a patient with multiple myeloma (MM) who had extramedullary relapse (paraspinal and thoracic masses and multiple cranial nerve palsy) after autologous and non-myeloablative allogeneic hematopoietic stem cell transplantation (HSCT).
منابع مشابه
Stem cell transplantation in multiple myeloma.
Multiple myeloma (MM) is one of the key hematologic malignancies in which the impact of dose intensity has been demonstrated. Consequently, in 2005, MM was the most common disease for which autologous stem cell transplantation (ASCT) was indicated both in Europe and in the U.S. However, ASCT is not curative, and most patients relapse within a median of 3 years. Novel agents such as thalidomide ...
متن کاملOutcome of allogeneic hematopoietic stem-cell transplantation for multiple myeloma: retrospective analysis of 16 patients
The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) for multiple myeloma (MM) has not yet been established. We performed allo-SCT on 16 patients with MM in our hospital and an associated center, and retrospectively evaluated its efficacy. The median age at allo-SCT was 47 years. Eight patients underwent allo-SCT as a front-line therapy. Non-myeloablative treatment was prov...
متن کاملRole of Allogeneic Transplantation in Multiple Myeloma in the Era of New Drugs
High-dose melphalan with autologous stem cell rescue has been regarded as the standard of care for patients with newly diagnosed myeloma up to the age of 65-70 years. The recent development of agents with potent anti-tumor activity such as thalidomide, lenalidomide and bortezomib has further improved overall survival and response rates. However, relapse is a continuous risk.Allografting is a po...
متن کاملMetastatic Pulmonary Calcinosis and Leukocytoclastic Vasculitis in a Patient with Multiple Myeloma
UNLABELLED Both leukocytoclastic vasculitis and metastatic pulmonary calcification are conditions that rarely occur during the course of multiple myeloma. We present a multiple myeloma patient that had severe dyspnea due to metastatic pulmonary calcinosis, and ulceronecrotic skin lesions caused by leukocytoclastic vasculitis. After 3 courses of standarddose chemotherapy all skin and pulmonary l...
متن کاملAdvances in the autologous and allogeneic transplantation strategies for multiple myeloma.
BACKGROUND Multiple myeloma is largely an incurable malignant plasma cell neoplasm; however, the landscape of its treatment is rapidly changing. METHODS The recent literature on both autologous and allogeneic transplant approaches for multiple myeloma was reviewed. RESULTS High-dose chemotherapy followed by autologous hematopoietic cell transplantation (HCT) remains an integral component of...
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ورودعنوان ژورنال:
- Haematologica
دوره 90 2 شماره
صفحات -
تاریخ انتشار 2005